报告人：Shemin Lu, PhD, Professor/Doctoral supervisor. He is the Chairman of the Shaanxi Society of Biochemistry and Molecular Biology; the Special Allowance Winner of State Council; the Sanqin Talent. He was awarded the outstanding graduate tutor of Xi'an Jiaotong University in 2017 (the 1st batch) and the advanced individual for teaching and educating (the 7th batch). His main research area is molecular pathogenesis and identification of susceptible genes of chronic inflammatory diseases, construction and evaluation of animal models. He has undertaken 1 key project of Natural Science Foundation of China (NSFC) and 4 general projects of NSFC, has published 132 SCI papers, including 74 SCI papers published as the first author/corresponding author, and has written/compiled 4 textbooks as editor-in-chief.
摘 要：Selenium is an essential trace element in the human body. Its deficiency associates with tumors, immune diseases, cardiovascular diseases and metabolic diseases, and also is considered as an environmental risk factor for two endemic diseases in northern China: Keshan disease and Kashin-Beck disease. There is a long history for research on selenium biology in our university. The research team of our university won the Klaus Swasch Prize of the International Union of Inorganic Biochemistry twice times, due to the excellent work in discovering the relationship between selenium and Keshan disease and Kashin-Beck disease. Selenium plays its biological roles by 25 selenoproteins, which are essential for the normal development, the normal structures and functions of cartilage. The understanding of the role and molecular mechanism of selenium on cartilage not only enriches the theory of selenium biology, but also contributes to the development of new treatment of osteochondrosis.
硒是人体必需的微量元素, 其缺乏与肿瘤、免疫疾病、心血管疾病及代谢性疾病有关，也被认为是我国北方地方病：克山病和大骨节病的环境危险因子。我校有长期研究硒生物学的传统，由于在发现硒和克山病、大骨节病的关系方面的卓越工作，两次获得国际无机生物化学联合会克劳斯 斯瓦施奖。硒通过25种硒蛋白发挥生物学作用，它们对软骨的正常发育及正常结构和功能的维护至关重要。充分了解硒对软骨的作用及分子机制，不但丰富了硒生物学的理论，也有助于开发新的骨软骨疾病干预措施。